| Date | Home
| Score | Away
|
| 28/08/2010 | Ballymena RFC | 52 - 22 | Rainey Old Boys |
| 28/08/2010 | Belfast Harlequins | 7 - 13 | Malone |
| 28/08/2010 | Banbridge | 7 - 50 | City of Derry |
| 28/08/2010 | Ballynahinch | 59 - 15 | Queens University |
| 28/08/2010 | Dungannon | 29 - 12 | Instonians |
| 04/09/2010 | City of Derry | vs | Belfast Harlequins |
| 04/09/2010 | Banbridge | vs | Queens University |
| 04/09/2010 | Rainey Old Boys | vs | Ballynahinch |
| 04/09/2010 | Malone | vs | Dungannon |
| 04/09/2010 | Ards | vs | Ballymena RFC |
| 11/09/2010 | Ballynahinch | vs | Ards |
| 15/09/2010 | Banbridge | vs | Rainey Old Boys |
| 15/09/2010 | Instonians | vs | Malone |
| 15/09/2010 | Dungannon | vs | City of Derry |
| 15/09/2010 | Belfast Harlequins | vs | Queens University |
| 18/09/2010 | Rainey Old Boys | vs | Belfast Harlequins |
| 18/09/2010 | Ards | vs | Banbridge |
| 18/09/2010 | City of Derry | vs | Instonians |
| 18/09/2010 | Ballymena RFC | vs | Ballynahinch |
| 18/09/2010 | Queens University | vs | Dungannon |
| 25/09/2010 | Belfast Harlequins | vs | Ards |
| 25/09/2010 | Malone | vs | City of Derry |
| 25/09/2010 | Dungannon | vs | Rainey Old Boys |
| 25/09/2010 | Banbridge | vs | Ballymena RFC |
| 20/11/2010 | Ards | vs | Dungannon |
| 20/11/2010 | Rainey Old Boys | vs | Instonians |
| 20/11/2010 | Ballynahinch | vs | Banbridge |
| 20/11/2010 | Ballymena RFC | vs | Belfast Harlequins |
| 20/11/2010 | Queens University | vs | Malone |
| 11/12/2010 | Malone | vs | Rainey Old Boys |
| 11/12/2010 | Belfast Harlequins | vs | Ballynahinch |
| 11/12/2010 | Dungannon | vs | Ballymena RFC |
| 11/12/2010 | City of Derry | vs | Queens University |
| 11/12/2010 | Instonians | vs | Ards |
| 18/12/2010 | Instonians | vs | Queens University |
| 08/01/2011 | Ballymena RFC | vs | Instonians |
| 08/01/2011 | Ards | vs | Malone |
| 08/01/2011 | Rainey Old Boys | vs | City of Derry |
| 08/01/2011 | Banbridge | vs | Belfast Harlequins |
| 08/01/2011 | Ballynahinch | vs | Dungannon |
| 15/01/2011 | Malone | vs | Ballymena RFC |
| 15/01/2011 | Queens University | vs | Rainey Old Boys |
| 15/01/2011 | City of Derry | vs | Ards |
| 15/01/2011 | Dungannon | vs | Banbridge |
| 15/01/2011 | Instonians | vs | Ballynahinch |
| 22/01/2011 | Belfast Harlequins | vs | Dungannon |
| 22/01/2011 | Banbridge | vs | Instonians |
| 22/01/2011 | Ballynahinch | vs | Malone |
| 22/01/2011 | Ballymena RFC | vs | City of Derry |
| 22/01/2011 | Ards | vs | Queens University |
| 05/03/2011 | City of Derry | vs | Ballynahinch |
| 05/03/2011 | Queens University | vs | Ballymena RFC |
| 05/03/2011 | Rainey Old Boys | vs | Ards |
| 05/03/2011 | Instonians | vs | Belfast Harlequins |
| 05/03/2011 | Malone | vs | Banbridge |